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Article

Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors.

Disease models & mechanisms - 1 Jul 2024

Chiang Hung-Ju, Nishiwaki Yuko, Chiang Wei-Chieh, Masai Ichiro

Abstract excerpt

Vertebrate photoreceptors are highly specialized retinal neurons that have cilium-derived membrane organelles called outer segments, which function as platforms for phototransduction. Male germ cell-associated kinase (MAK) is a cilium-associated serine/threonine kinase, and its genetic mutation causes photoreceptor degeneration in mice and retinitis pigmentosa in humans. However, the role of MAK in photoreceptors...

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Share to Axoneme
Share to Cell Survival
Share to Cilia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Photoreceptor Cells, Vertebrate

Share to Protein Serine-Threonine Kinases

Share to Retinal Rod Photoreceptor Cells

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Source

Open in PubMed Open full text

Identifiers

PMID: 38813692
DOI: 10.1242/dmm.050618
PMCID: PMC11273301

Genes

MAK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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