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Article

Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.

American journal of physiology. Cell physiology - 1 Dec 2017

Keller Alexander S, Diederich Lukas, Panknin Christina, DeLalio Leon J, Drake Joshua C, Sherman Robyn, Jackson Edwin Kerry, Yan Zhen, Kelm Malte, Cortese-Krott Miriam M, Isakson Brant E

Abstract excerpt

Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle. In ex vivo settings RBCs have been shown to release ATP in response to a number of stimuli, including stimulation of adrenergic receptors. Further evidence suggested that ATP release from RBCs was dependent on activation of adenylate cyclase (AC)/cyclic...

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Identifiers

PMID: 28855161
DOI: 10.1152/ajpcell.00178.2017
PMCID: PMC5814586

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