Article
X-linked inhibitor of apoptosis protein (XIAP) regulation of cyclin D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis.
The Journal of biological chemistry - 12 Jul 2013
Cao Zipeng, Zhang Ruowen, Li Jingxia, Huang Haishan, Zhang Dongyun, Zhang Jingjie, Gao Jimin, Chen Jingyuan, Huang Chuanshu
Abstract excerpt
The X-linked inhibitor of apoptosis protein (XIAP) is a well known potent inhibitor of apoptosis; however, it is also involved in other cancer cell biological behavior. In the current study, we discovered that XIAP and its E3 ligase played a crucial role in regulation of cyclin D1 expression in c...
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