Article
Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.
Molecular cell - 16 Sept 2021
Chen Dong, Xia Siyuan, Zhang Rukang, Li Yuancheng, Famulare Christopher A, Fan Hao, Wu Rong, Wang Mei, Zhu Allen C, Elf Shannon E, Su Rui, Dong Lei, Arellano Martha, Blum William G, Mao Hui, Lonial Sagar, Stock Wendy, Odenike Olatoyosi, Le Beau Michelle, Boggon Titus J, He Chuan, Chen Jianjun, Gao Xue, Levine Ross L, Chen Jing
Abstract excerpt
Mutant isocitrate dehydrogenase (IDH) 1 and 2 play a pathogenic role in cancers, including acute myeloid leukemia (AML), by producing oncometabolite 2-hydroxyglutarate (2-HG). We recently reported that tyrosine phosphorylation activates IDH1 R132H mutant in AML cells. Here, we show that mutant IDH2 (mIDH2) R140Q commonly has K413 acetylation, which negatively regulates mIDH2 activity in human AML cells by...
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