Putrescine independent wound response phenotype is produced by ODC-like RNAi in planarians.

doi:10.1038/s41598-017-09567-6

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Article

Putrescine independent wound response phenotype is produced by ODC-like RNAi in planarians.

Scientific reports - 29 Aug 2017

Cassella Lucia, Salvetti Alessandra, Iacopetti Paola, Ippolito Chiara, Ghezzani Claudio, Gimenez Gregory, Ghigo Eric, Rossi Leonardo

Abstract excerpt

Despite increasing evidence indicates polyamines as a convergence point for signaling pathways, including cell growth and differentiation, a unifying concept to interpret their role is still missing. The activity of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is tightly regulated by a complex molecular machinery, and the demonstration of the existence of multiple ODC...

Topics

Animals
Cell Proliferation
Gene Expression Regulation, Enzymologic
Gene Silencing
In Situ Hybridization
Ornithine Decarboxylase
Phenotype
Planarians
Polyamines
Putrescine
RNA Interference
RNA, Double-Stranded

Source

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Identifiers

PMID: 28851936
DOI: 10.1038/s41598-017-09567-6
PMCID: PMC5574924

Genes

ODC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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