Article
A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation.
Proceedings of the National Academy of Sciences of the United States of America - 11 Mar 2008
Jarriault Sophie, Schwab Yannick, Greenwald Iva
Abstract excerpt
Understanding transdifferentiation-the conversion of one differentiated cell type into another-is important from both basic science and clinical perspectives. In Caenorhabditis elegans, an epithelial cell named Y is initially part of the rectum but later appears to withdraw, migrate, and then become a motor neuron named PDA. Here, we show that this represents a bona fide transdifferentiation event: Y has...
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