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Article

Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.

Developmental cell - 1 May 2005

Reddien Peter W, Bermange Adam L, Murfitt Kenneth J, Jennings Joya R, Sánchez Alvarado Alejandro

Abstract excerpt

Planarians have been a classic model system for the study of regeneration, tissue homeostasis, and stem cell biology for over a century, but they have not historically been accessible to extensive genetic manipulation. Here we utilize RNA-mediated genetic interference (RNAi) to introduce large-scale gene inhibition studies to the classic planarian system. 1065 genes were screened. Phenotypes associated with the...

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Identifiers

PMID: 15866156
DOI: 10.1016/j.devcel.2005.02.014
PMCID: PMC2267917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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