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Article

MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury.

Circulation research - 29 Sept 2017

DeBerge Matthew, Yeap Xin Yi, Dehn Shirley, Zhang Shuang, Grigoryeva Lubov, Misener Sol, Procissi Daniel, Zhou Xin, Lee Daniel C, Muller William A, Luo Xunrong, Rothlin Carla, Tabas Ira, Thorp Edward B

Abstract excerpt

RATIONALE: Clinical benefits of reperfusion after myocardial infarction are offset by maladaptive innate immune cell function, and therapeutic interventions are lacking. OBJECTIVE: We sought to test the significance of phagocytic clearance by resident and recruited phagocytes after myocardial ischemia reperfusion. METHODS AND RESULTS: In humans, we discovered that clinical reperfusion after myocardial infarction...

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Share to c-Mer Tyrosine Kinase
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monocytes

Share to Myocardial Reperfusion Injury

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Share to Proteolysis

Share to Receptor Protein-Tyrosine Kinases

Share to Receptors, CCR2

Source

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Identifiers

PMID: 28851810
DOI: 10.1161/CIRCRESAHA.117.311327
PMCID: PMC5623080

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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