Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative model of leukocyte genomics and organ dysfunction in heart failure patients requiring mechanical circulatory support: a prospective observational study.

BMC medical genomics - 29 Aug 2017

Wisniewski Nicholas, Bondar Galyna, Rau Christoph, Chittoor Jay, Chang Eleanor, Esmaeili Azadeh, Cadeiras Martin, Deng Mario

Abstract excerpt

BACKGROUND: The implantation of mechanical circulatory support devices in heart failure patients is associated with a systemic inflammatory response, potentially leading to death from multiple organ dysfunction syndrome. Previous studies point to the involvement of many mechanisms, but an integrative hypothesis does not yet exist. Using time-dependent whole-genome mRNA expression in circulating leukocytes, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Genomics

Share to Heart Failure

Share to Leukocytes, Mononuclear

Share to Multiple Organ Failure

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 28851355
DOI: 10.1186/s12920-017-0288-8
PMCID: PMC5576384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative model of leukocyte genomics and organ dysfunction in heart failure patients requiring mechanical circulatory support: a prospective observational study.PMID 28851355Read ↗

An integrative model of leukocyte genomics and organ dysfunction in heart failure patients requiring mechanical circulatory supportSemantic proximity Read ↗

Multimarker profiling identifies protective and harmful immune processes in heart failure: findings from BIOSTAT-CHFSemantic proximity Read ↗

404-Error “Disease Not Found”: Unleashing the Translational Potential of -Omics Approaches Beyond Traditional Disease Classification in Heart Failure ResearchSemantic proximity Read ↗

Prioritizing Candidates of Post–Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell TranscriptomicsSemantic proximity Read ↗

Weighted Gene Coexpression Network Analysis (WGCNA) Modeling of Multiorgan Dysfunction Syndrome after Mechanical Circulatory Support TherapySemantic proximity Read ↗

Integrative System Biology Analyses Identify Seven Micrornas to Predict Heart FailureSemantic proximity Read ↗

A translational genomics approach to dissect mechanisms of heart failure and recoverySemantic proximity Read ↗

Whole Blood Transcriptomics in Cardiac Surgery Identifies a Gene Regulatory Network Connecting Ischemia Reperfusion with Systemic InflammationSemantic proximity Read ↗

Strategies to Minimize Heterogeneity and Optimize Clinical Trials in Acute Respiratory Distress Syndrome (ARDS): Insights from Mathematical ModelingSemantic proximity Read ↗

Validation of Immune Cell Modules in Multicellular Transcriptomic DataSemantic proximity Read ↗

A Network medicine approach to study comorbidities in heart failure with preserved ejection fractionSemantic proximity Read ↗

Weighted gene coexpression network analysis of human left atrial tissue identifies gene modules associated with atrial fibrillation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.