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Article

Validation of Immune Cell Modules in Multicellular Transcriptomic Data

3 Jan 2017

Abstract excerpt

Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular tissue samples. However, significant diversity in module gene content for specific cell types is associated with heterogeneity in their performance. In order to rank modules that best reflect their purported association, we have generated the modular discrimination index (MDI) score...

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PMID: 28045996
DOI: 10.1371/journal.pone.0169271

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