Article
Weighted gene coexpression network analysis of human left atrial tissue identifies gene modules associated with atrial fibrillation.
Circulation. Cardiovascular genetics - 1 Aug 2013
Tan Nicholas, Chung Mina K, Smith Jonathan D, Hsu Jeffrey, Serre David, Newton David W, Castel Laurie, Soltesz Edward, Pettersson Gosta, Gillinov A Marc, Van Wagoner David R, Barnard John
Abstract excerpt
BACKGROUND: Genetic mechanisms of atrial fibrillation (AF) remain incompletely understood. Previous differential expression studies in AF were limited by small sample size and provided limited understanding of global gene networks, prompting the need for larger-scale, network-based analyses. METHODS AND RESULTS: Left atrial tissues from Cleveland Clinic patients who underwent cardiac surgery were assayed using...
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