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Tumor endothelial cells with high aldehyde dehydrogenase activity show drug resistance

29 Aug 2017

Abstract excerpt

Tumor blood vessels play an important role in tumor progression and metastasis. We previously reported that tumor endothelial cells (TEC) exhibit several altered phenotypes compared with normal endothelial cells (NEC). For example, TEC have chromosomal abnormalities and are resistant to several anticancer drugs. Furthermore, TEC contain stem cell‐like populations with high aldehyde dehydrogenase (ALDH) activity...

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PMID: 28851003
DOI: 10.1111/cas.13388

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