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Aldehyde Dehydrogenase 1, a Potential Marker for Cancer Stem Cells in Human Sarcoma

23 Aug 2012

Abstract excerpt

Tumors contain a small population of cancer stem cells (CSC) proposed to be responsible for tumor maintenance and relapse. Aldehyde dehydrogenase 1 (ALDH1) activity has been used as a functional stem cell marker to isolate CSCs in different cancer types. This study used the Aldefluor® assay and fluorescence-activated cell sorting (FACS) analysis to isolate ALDH1(high) cells from five human sarcoma cell lines and...

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PMID: 22928012
DOI: 10.1371/journal.pone.0043664

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