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Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance

25 Jun 2010

Abstract excerpt

Elevated aldehyde dehydrogenase 1 (ALDH1) has been proposed as one of the possible candidates for a stem cell maker that can be used for the isolation of cancer stem cells from cancers such as leukemia and breast cancer. In the current study, we found that subpopulations with elevated ALDH1 were present in the human sarcoma cell lines, MG63 (osteosarcoma) and HT1080 (fibrosarcoma), using Aldefluor assay. Both...

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PMID: 20596639
DOI: 10.3892/or_00000885

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