Article
Modelling the drivers of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan Africa.
eLife - 24 Aug 2017
Watson Oliver J, Slater Hannah C, Verity Robert, Parr Jonathan B, Mwandagalirwa Melchior K, Tshefu Antoinette, Meshnick Steven R, Ghani Azra C
Abstract excerpt
Rapid diagnostic tests (RDTs) have transformed malaria diagnosis. The most prevalent P. falciparum RDTs detect histidine-rich protein 2 (PfHRP2). However, pfhrp2 gene deletions yielding false-negative RDTs, first reported in South America in 2010, have been confirmed in Africa and Asia. We developed a mathematical model to explore the potential for RDT-led diagnosis to drive selection of pfhrp2-deleted parasites....
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