Article

Causes of false-negative rapid diagnostic tests for symptomatic malaria in the DRC

2020-08-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The majority of Plasmodium falciparum malaria diagnoses in Africa are made using rapid diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports of false-negative RDT results due to parasites with deletions of the pfhrp2 and/or pfhrp3 genes ( pfhrp2/3 ) raise concern about existing malaria diagnostic strategies. We previously identified pfhrp2- negative...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 845ad82c-5cf2-50e7-85c5-af3dc699168f
DOI: 10.1101/2020.08.25.20181354

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Causes of false-negative rapid diagnostic tests for symptomatic malaria in the DRCDOI 10.1101/2020.08.25.20181354Read

Analysis of false-negative rapid diagnostic tests for symptomatic malaria in the Democratic Republic of the CongoSemantic proximity Read

Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients in the DRC enrolled from 2017 to 2018Semantic proximity Read

Deletions of the Plasmodium falciparum pfhrp2 and pfhrp3 genes among patients enrolled at six locations in the DRC: 2017–2018Semantic proximity Read

Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from UgandaSemantic proximity Read

Low prevalence of Plasmodium falciparum parasites lacking pfhrp2/3 genes among asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of CongoSemantic proximity Read

Community-based surveys for Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions in selected regions of mainland TanzaniaSemantic proximity Read

Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from UgandaSemantic proximity Read

<i>Plasmodium falciparum w</i>ith<i>pfhrp2/3</i>deletion not detected in a 2018-2021 malaria longitudinal cohort study in Kinshasa Province, Democratic Republic of the CongoSemantic proximity Read

Evaluating Malaria Rapid Diagnostic Tests and Microscopy for Detecting Plasmodium Infection and Status of Plasmodium falciparum Histidine-Rich Protein 2/3 Gene Deletions in Southeastern NigeriaSemantic proximity Read

Prevalence of Plasmodium falciparum Isolates Lacking the Histidine Rich Protein 2 Gene Among Symptomatic Malaria Patients in Kwilu Province, DR. Congo.Semantic proximity Read

Streamlined, PCR-based testing for pfhrp2- and pfhrp3-negative Plasmodium falciparumSemantic proximity Read

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South SudanSemantic proximity Read