Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes.

doi:10.1038/s41598-017-08300-7

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Article

Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes.

Scientific reports - 23 Aug 2017

Schüler Rita, Osterhoff Martin A, Frahnow Turid, Möhlig Matthias, Spranger Joachim, Stefanovski Darko, Bergman Richard N, Xu Li, Seltmann Anne-Cathrin, Kabisch Stefan, Hornemann Silke, Kruse Michael, Pfeiffer Andreas F H

Abstract excerpt

The frequent ACE insertion/deletion polymorphism (I/D) is, albeit inconsistently, associated with impaired glucose tolerance and insulin resistance. We recently observed an enhanced upregulation of ACE by elevated fat intake in GG-carriers of the I/D-surrogate rs4343 variant and therefore investigated its potential nutrigenetic role in glucose metabolism. In this nutritional intervention study 46 healthy and...

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PMID: 28835639
DOI: 10.1038/s41598-017-08300-7
PMCID: PMC5569105

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