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Article

Is the influence of variation in the ACE gene on the prospective risk of Type 2 diabetes in middle-aged men modified by obesity?

Clinical science (London, England : 1979) - 1 Dec 2007

Muthumala Amal, Gable David R, Palmen Jutta, Cooper Jackie A, Stephens Jeffrey W, Miller George J, Humphries Steve E

Abstract excerpt

There is strong evidence for the presence of a functional renin-angiotensin system in diabetogenic tissues, and ACE (angiotensin-converting enzyme) inhibitors may improve glucose metabolism in those individuals at high risk of developing T2DM (Type 2 diabetes). In the present study, we tested the hypothesis that subjects with genetically lower plasma and tissue ACE activity, because of their ACE [I/D...

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Body Mass Index
Diabetes Mellitus, Type 2
ACE gene
Genetic Predisposition to Disease
Genotype

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Peptidyl-Dipeptidase A

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PMID: 17624939
DOI: 10.1042/CS20070158

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ACE

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