Article
Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial.
The American journal of clinical nutrition - 1 Sept 2017
Goni Leticia, Qi Lu, Cuervo Marta, Milagro Fermín I, Saris Wim H, MacDonald Ian A, Langin Dominique, Astrup Arne, Arner Peter, Oppert Jean-Michel, Svendstrup Mathilde, Blaak Ellen E, Sørensen Thorkild Ia, Hansen Torben, Martínez J Alfredo
Abstract excerpt
Background: Circulating branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) have been shown to be associated with insulin resistance and diabetes risk. The common rs1440581 T allele in the protein phosphatase Mg2+/Mn2+ dependent 1K (PPM1K) gene has been related to elevated BCAA concentrations and risk of type 2 diabetes.Objective: In the present study, we tested whether dietary fat and carbohydrate...
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