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Article

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.

Blood - 14 Aug 2014

Pohl Kerstin, Hayes Elaine, Keenan Joanne, Henry Michael, Meleady Paula, Molloy Kevin, Jundi Bakr, Bergin David A, McCarthy Cormac, McElvaney Oliver J, White Michelle M, Clynes Martin, Reeves Emer P, McElvaney Noel G

Abstract excerpt

Studies have endeavored to reconcile whether dysfunction of neutrophils in people with cystic fibrosis (CF) is a result of the genetic defect or is secondary due to infection and inflammation. In this study, we illustrate that disrupted function of the CF transmembrane conductance regulator (CFTR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24934256
DOI: 10.1182/blood-2014-02-555268
PMCID: PMC4133506

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24934256-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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