Article
Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions.
Neurological research - 1 Nov 2017
Eryilmaz Isil Ezgi, Cecener Gulsah, Erer Sevda, Egeli Unal, Tunca Berrin, Zarifoglu Mehmet, Elibol Bulent, Bora Tokcaer Ayse, Saka Esen, Demirkiran Meltem, Akbostanci Cenk, Dogu Okan, Colakoglu Beril, Kenangil Gulay, Kaleagasi Hakan
Abstract excerpt
Background and aim The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD). Materials and methods The promoter region methylation status of SNCA and PARK2 genes was evaluated by methylation specific-PCR (MSP) in 91 patients with...
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