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Article

Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH

17 Mar 2007

Abstract excerpt

Idiopathic pulmonary arterial hypertension (IPAH) in human patients is associated with mutations in type 2 receptor for the bone morphogenic protein pathway (BMPR2). Mice expressing an inducible dominant negative form of BMPR2 in smooth muscle develop elevated right ventricular pressures when the transgene is activated. We hypothesized that transcriptional changes in these mice may allow insight into the early...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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Identifiers

PMID: 17369292
DOI: 10.1152/ajplung.00305.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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