Article
Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol.
Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 2017
Alvarez Monica I, Glover Luke C, Luo Peter, Wang Liuyang, Theusch Elizabeth, Oehlers Stefan H, Walton Eric M, Tram Trinh Thi Bich, Kuang Yu-Lin, Rotter Jerome I, McClean Colleen M, Chinh Nguyen Tran, Medina Marisa W, Tobin David M, Dunstan Sarah J, Ko Dennis C
Abstract excerpt
Risk, severity, and outcome of infection depend on the interplay of pathogen virulence and host susceptibility. Systematic identification of genetic susceptibility to infection is being undertaken through genome-wide association studies, but how to expeditiously move from genetic differences to functional mechanisms is unclear. Here, we use genetic association of molecular, cellular, and human disease traits and...
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