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Article

ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.

PLoS pathogens - 1 Jul 2021

Bourgeois Jeffrey S, Wang Liuyang, Rabino Agustin F, Everitt Jeffrey, Alvarez Monica I, Awadia Sahezeel, Wittchen Erika S, Garcia-Mata Rafael, Ko Dennis C

Abstract excerpt

Salmonella hijack host machinery in order to invade cells and establish infection. While considerable work has described the role of host proteins in invasion, much less is known regarding how natural variation in these invasion-associated host proteins affects Salmonella pathogenesis. Here we leveraged a candidate cellular GWAS screen to identify natural genetic variation in the ARHGEF26 (Rho Guanine Nucleotide...

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Identifiers

PMID: 34242364
DOI: 10.1371/journal.ppat.1009713
PMCID: PMC8294491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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