Accurate detection of subclonal variants in paired diagnosis-relapse acute myeloid leukemia samples by next generation Duplex Sequencing.

Abstract excerpt

Mutations characterize diverse human cancers; there is a positive correlation between elevated mutation frequency and tumor progression. One exception is acute myeloid leukemia (AML), which has few clonal single nucleotide mutations. We used highly sensitive and accurate Duplex Sequencing (DS) to show now that AML, in addition, has an extensive repertoire of variants with low allele frequencies, < 1%, which is...

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• Acute Myeloid Leukemia Research
• Alleles
• Cancer Genomics and Diagnostics
• Genomics and Rare Diseases
• High-Throughput Nucleotide Sequencing