Article
An L319F mutation in transmembrane region 3 (TM3) selectively reduces sensitivity to okaramine B of the Bombyx mori l-glutamate-gated chloride channel.
Bioscience, biotechnology, and biochemistry - 1 Oct 2017
Furutani Shogo, Okuhara Daiki, Hashimoto Anju, Ihara Makoto, Kai Kenji, Hayashi Hideo, Sattelle David B, Matsuda Kazuhiko
Abstract excerpt
Okaramines produced by Penicillium simplicissimum AK-40 activate l-glutamate-gated chloride channels (GluCls) and thus paralyze insects. However, the okaramine binding site on insect GluCls is poorly understood. Sequence alignment shows that the equivalent of residue Leucine319 of the okaramine B sensitive Bombyx mori (B. mori) GluCl is a phenylalanine in the okaramine B insensitive B. mori γ-aminobutyric...
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