Article
Mutations on M3 helix of Plutella xylostella glutamate-gated chloride channel confer unequal resistance to abamectin by two different mechanisms.
Insect biochemistry and molecular biology - 1 Jul 2017
Wang Xingliang, Puinean Alin M, O Reilly Andrias O, Williamson Martin S, Smelt Charles L C, Millar Neil S, Wu Yidong
Abstract excerpt
Abamectin is one of the most widely used avermectins for agricultural pests control, but the emergence of resistance around the world is proving a major threat to its sustained application. Abamectin acts by directly activating glutamate-gated chloride channels (GluCls) and modulating other Cys-loop ion channels. To date, three mutations occurring in the transmembrane domain of arthropod GluCls are associated...
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