Article
Downregulation of SMARCB1/INI1 expression in pediatric chordomas correlates with upregulation of miR-671-5p and miR-193a-5p expressions.
Brain tumor pathology - 1 Oct 2017
Malgulwar Prit Benny, Pathak Pankaj, Singh Manmohan, Kale Shashank Sharad, Suri Vaishali, Sarkar Chitra, Sharma Mehar Chand
Abstract excerpt
Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas (CCs). Although mutation/loss of 22q has strongly established the loss of SMARCB1/INI1 in cancers, the cause in CCs remains elusive. Recent studies suggest role of miRNAs in regulation of SMARCB1/INI1 expressions. We examined 5 reported/target predicted miRNAs to SMARCB1/INI1 in SMARCB1/INI1 immunonegative and immunopositive...
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