Article
Loss of SMARCB1/INI1 expression in poorly differentiated chordomas.
Acta neuropathologica - 1 Dec 2010
Mobley Bret C, McKenney Jesse K, Bangs Charles D, Callahan Katherine, Yeom Kristen W, Schneppenheim Reinhard, Hayden Melanie G, Cherry Athena M, Gokden Murat, Edwards Michael S B, Fisher Paul G, Vogel Hannes
Abstract excerpt
Chordomas are malignant neoplasms that typically arise in the axial spine and primarily affect adults. When chordomas arise in pediatric patients they are more likely to display unusual histological features and aggressive behavior. We noted the absence of SMARCB1/INI1 expression by immunohistochemistry in an index case of poorly differentiated chordoma of the sacrum, leading us to further examine SMARCB1/INI1...
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