Functional IGF1R variant predicts breast cancer risk in women with preeclampsia in California Teachers Study.

doi:10.1007/s10552-017-0942-7

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Functional IGF1R variant predicts breast cancer risk in women with preeclampsia in California Teachers Study.

Cancer causes & control : CCC - 1 Oct 2017

Powell Mark J, Von Behren Julie, Neuhausen Susan, Reynolds Peggy, Benz Christopher C

Abstract excerpt

PURPOSE: Hypertension in pregnancy has been associated with decreased future risk of breast cancer in many but not all studies. In the Marin Women's Study, pregnancy-induced hypertension was shown to interact with the T allele of a functional IGF1R gene variant, rs2016347, to result in lower breast density, as well as decreased breast cancer risk. Our objective was to explore these findings in a larger sample of...

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PMID: 28822014
DOI: 10.1007/s10552-017-0942-7
PMCID: PMC5613056

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