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Article

A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth.

BMC medicine - 17 Jul 2023

Wang Li, Rossi Robert M, Chen Xiaoting, Chen Jing, Runyon Jilian, Chawla Mehak, Miller Daniel, Forney Carmy, Lynch Arthur, Zhang Xuzhe, Kong Fansheng, Jacobsson Bo, Kottyan Leah C, Weirauch Matthew T, Zhang Ge, Muglia Louis J

Abstract excerpt

BACKGROUND: Preterm birth (PTB), defined as delivery before 37 gestational weeks, imposes significant public health burdens. A recent maternal genome-wide association study of spontaneous PTB identified a noncoding locus near the angiotensin II receptor type 2 (AGTR2) gene. Genotype-Tissue Expression data revealed that alleles associated with decreased AGTR2 expression in the uterus were linked to an increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37455310
DOI: 10.1186/s12916-023-02973-w
PMCID: PMC10351137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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