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Article

Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cγ-mediated FAK/ERK signaling pathway in colon cancer.

The Journal of biological chemistry - 29 Sept 2017

Jang Bohee, Jung Hyejung, Choi Sojoong, Lee Young Hun, Lee Seung-Taek, Oh Eok-Soo

Abstract excerpt

The syndecan family of heparan sulfate proteoglycans contributes to cell adhesion and communication by serving as co-receptors for cell signaling and extracellular matrix molecules. Syndecan-2 is located at the cell surface, and we previously reported that it induces matrix metalloproteinase-7 (MMP-7) expression in colon cancer cells. However, the underlying regulatory mechanisms are unknown. Here, we report that...

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Source

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Identifiers

PMID: 28821612
DOI: 10.1074/jbc.M117.793752
PMCID: PMC5625061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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