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Article

Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells.

Experimental cell research - 1 Feb 2006

Hirao Takafumi, Nanba Daisuke, Tanaka Motonari, Ishiguro Hiroshi, Kinugasa Yumi, Doki Yuichiro, Yano Masahiko, Matsuura Nariaki, Monden Morito, Higashiyama Shigeki

Abstract excerpt

Growth factor-mediated stimulation of epithelial cells induces the disassembly of E-cadherin-mediated cell-cell adhesion. We found that overexpression of a disintegrin and metalloprotease 9 (ADAM9) enhanced growth factor-mediated induction of endocytosis and dynamic recycling of E-cadherin in HT29 human colon cancer cells. In addition, ubiquitination and degradation of E-cadherin were reduced in these cells....

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Source

Identifiers

PMID: 16336960
DOI: 10.1016/j.yexcr.2005.10.032

Genes

ADAM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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