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Article

Mutations within the env gene of Mason-Pfizer monkey virus: effects on protein transport and SU-TM association.

Journal of virology - 1 Jun 1992

Brody B A, Hunter E

Abstract excerpt

By deletion mutagenesis analyses, we have examined the contribution of the immunosuppressive peptide (ISP) region within the transmembrane (TM) protein of Mason-Pfizer monkey virus to viral maturation and infectivity. Deletion of the entire region (mutant D105) results in the production of an Env precursor that is transport defective and therefore unable to be processed to mature glycoproteins. This mutation...

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Identifiers

PMID: 1316462
DOI: 10.1128/JVI.66.6.3466-3475.1992
PMCID: PMC241127

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