Article
Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses.
Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2010
Schlecht-Louf Géraldine, Renard Martial, Mangeney Marianne, Letzelter Claire, Richaud Aurélien, Ducos Bertrand, Bouallaga Isabelle, Heidmann Thierry
Abstract excerpt
We previously delineated a highly conserved immunosuppressive (IS) domain within murine and primate retroviral envelope proteins (Envs). The envelope-mediated immunosuppression was manifested by the ability of the proteins, when expressed by allogeneic tumor cells normally rejected by engrafted mice, to allow these cells to escape, at least transiently, immune rejection. Using this approach, we identified key...
Topics
- Animals
- Friend murine leukemia virus
- Immune Tolerance
- Leukemia, Experimental
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- NIH 3T3 Cells
- Retroviridae Infections