Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conservative mutations in the immunosuppressive region of the bovine leukemia virus transmembrane protein affect fusion but not infectivity in vivo.

The Journal of biological chemistry - 22 May 1998

Gatot J S, Callebaut I, Mornon J P, Portetelle D, Burny A, Kerkhofs P, Kettmann R, Willems L

Abstract excerpt

Many retroviruses, including bovine leukemia virus (BLV), contain a highly conserved region located about 40 amino acids downstream from the fusion peptide within the sequence of the external domain of the transmembrane (TM) protein. This region is notably thought to be involved in the presentation of the NH2-terminal peptide to allow cell fusion. By using hydrophobic cluster analysis and by analogy with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Protein Conformation

Share to Sequence Homology, Amino Acid

Share to Viral Envelope Proteins

Share to Viral Load

Source

Identifiers

PMID: 9582317
DOI: 10.1074/jbc.273.21.12870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conservative mutations in the immunosuppressive region of the bovine leukemia virus transmembrane protein affect fusion but not infectivity in vivo.PMID 9582317Read ↗

Mutation of the Putative Immunosuppressive Domain of the Retroviral Envelope Glycoprotein Compromises Infectivity.Semantic proximity Read ↗

Identification and characterization of common B cell epitope in bovine leukemia virus via high-throughput peptide screening system in infected cattle.Semantic proximity Read ↗

Role of the proline-rich motif of bovine leukemia virus transmembrane protein gp30 in viral load and pathogenicity in sheep.Semantic proximity Read ↗

Natural genetic variations in bovine leukemia virus envelope gene: possible effects of selection and escape.Semantic proximity Read ↗

Three YXXL Sequences of a Bovine Leukemia Virus Transmembrane Protein are Independently Required for Fusion Activity by Controlling Expression on the Cell Membrane.Semantic proximity Read ↗

Mutation of a Single Envelope N-Linked Glycosylation Site Enhances the Pathogenicity of Bovine Leukemia Virus.Semantic proximity Read ↗

Sequence variability of bovine leukemia virus env gene and its relevance to the structure and antigenicity of the glycoproteins.Semantic proximity Read ↗

Functional analysis of the cytoplasmic tail of Moloney murine leukemia virus envelope protein.Semantic proximity Read ↗

Increase in infectivity of targeted Moloney murine leukemia virus-based gene-delivery vectors through lowering the threshold for fusion.Semantic proximity Read ↗

Membrane-proximal cytoplasmic domain of Moloney murine leukemia virus envelope tail facilitates fusion.Semantic proximity Read ↗

Determination of the minimal fusion peptide of bovine leukemia virus gp30.Semantic proximity Read ↗

Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.