Conservative mutations in the immunosuppressive region of the bovine leukemia virus transmembrane protein affect fusion but not infectivity in vivo.

doi:10.1074/jbc.273.21.12870

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Article

Conservative mutations in the immunosuppressive region of the bovine leukemia virus transmembrane protein affect fusion but not infectivity in vivo.

The Journal of biological chemistry - 22 May 1998

Gatot J S, Callebaut I, Mornon J P, Portetelle D, Burny A, Kerkhofs P, Kettmann R, Willems L

Abstract excerpt

Many retroviruses, including bovine leukemia virus (BLV), contain a highly conserved region located about 40 amino acids downstream from the fusion peptide within the sequence of the external domain of the transmembrane (TM) protein. This region is notably thought to be involved in the presentati...

Topics

Amino Acid Sequence
Leukemia Virus, Bovine
Models, Molecular
Molecular Sequence Data
Mutation
Protein Conformation
Retroviridae Proteins, Oncogenic
Sequence Homology, Amino Acid
Viral Envelope Proteins
Viral Load

Source

Open in PubMed

Identifiers

PMID: 9582317
DOI: 10.1074/jbc.273.21.12870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9582317-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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