Article
Detection of First-Line Drug Resistance Mutations and Drug-Protein Interaction Dynamics from Tuberculosis Patients in South India.
Microbial drug resistance (Larchmont, N.Y.) - 1 May 2018
Nachappa Somanna Ajjamada, Neelambike Sumana M, Amruthavalli Chokkanna, Ramachandra Nallur B
Abstract excerpt
BACKGROUND: Diagnosis of drug-resistant tuberculosis predominantly relies on culture-based drug susceptibility testing, which take weeks to produce a result and a more time-efficient alternative method is multiplex allele-specific PCR (MAS-PCR). Also, understanding the role of mutations in causing resistance helps better drug designing. AIMS: To evaluate the ability of MAS-PCR in the detection of drug resistance...
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