Article
Molecular modelling and docking analysis of katG and rpoB gene in MDR-TB isolates from North Central Indian population.
Journal of infection and public health - 1 Jan 2000
Prakash Ravi, Gupta Rahul, Katoch Vishwa M, Tiwari Pramod K
Abstract excerpt
Tuberculosis caused by Mycobacterium tuberculosis, requires multi drug therapy approach. Drug resistance in M. tuberculosis is caused by mutations in specific regions in drug target genes. The study aimed to identify mutations in katG and rpoB genes and investigate the drug-drug target interactions. A total of 27 MDR-TB isolates were sequenced for katG and rpoB genes and docking and MIC analysis were performed....
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