Article
Heritability Estimation using a Regularized Regression Approach (HERRA): Applicable to continuous, dichotomous or age-at-onset outcome.
PloS one - 1 Jan 2017
Gorfine Malka, Berndt Sonja I, Chang-Claude Jenny, Hoffmeister Michael, Le Marchand Loic, Potter John, Slattery Martha L, Keret Nir, Peters Ulrike, Hsu Li
Abstract excerpt
The popular Genome-wide Complex Trait Analysis (GCTA) software uses the random-effects models for estimating the narrow-sense heritability based on GWAS data of unrelated individuals without knowing and identifying the causal loci. Many methods have since extended this approach to various situations. However, since the proportion of causal loci among the variants is typically very small and GCTA uses all variants...
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