Article
Interdependence of Molecular Lesions That Drive Uveal Melanoma Metastasis.
International journal of molecular sciences - 26 Oct 2023
Reggiani Francesco, Ambrosio Marianna, Croce Michela, Tanda Enrica Teresa, Spagnolo Francesco, Raposio Edoardo, Petito Mariangela, El Rashed Zeinab, Forlani Alessandra, Pfeffer Ulrich, Amaro Adriana Agnese
Abstract excerpt
The metastatic risk of uveal melanoma (UM) is defined by a limited number of molecular lesions, somatic mutations (SF3B1 and BAP1), and copy number alterations (CNA): monosomy of chromosome 3 (M3), chr8q gain (8q), chr6p gain (6p), yet the sequence of events is not clear. We analyzed data from three datasets (TCGA-UVM, GSE27831, GSE51880) with information regarding M3, 8q, 6p, SF3B1, and BAP1 status. We confirm...
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