Article
GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi.
British journal of cancer - 5 Sept 2017
Vader M J C, Madigan M C, Versluis M, Suleiman H M, Gezgin G, Gruis N A, Out-Luiting J J, Bergman W, Verdijk R M, Jager M J, van der Velden P A
Abstract excerpt
BACKGROUND: Mutations in GNAQ/11 genes are considered an early event in the development of uveal melanoma that may derive from a pre-existing nevus. The Hippo pathway, by way of YAP activation, rather than MAP kinase, has a role in the oncogenic capacity of GNAQ/11 mutations. METHODS: We investigated 16 nevi from 13 human eyes for driver GNAQ/11 mutations using droplet digital PCR and determined whether nevi are...
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