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Evaluating Targeted Next-Generation Sequencing Assays and Reference Materials for NTRK Fusion Detection

15 Oct 2021

Abstract excerpt

Neurotrophic tyrosine receptor kinase (NTRK1/2/3) fusions are oncogenic drivers in approximately 0.3% of solid tumors. High-quality testing to identify patients with NTRK fusion-positive tumors who could benefit from tropomyosin receptor kinase inhibitors is recommended, but the current NTRK testing landscape, including next-generation sequencing (NGS), is fragmented and availability of assays varies widely. The...

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PMID: 34656759
DOI: 10.1016/j.jmoldx.2021.09.008

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