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A Performance Comparison of Commonly Used Assays to Detect RET Fusions

3 Dec 2020

Abstract excerpt

Abstract Purpose: Selpercatinib and pralsetinib induce deep and durable responses in patients with advanced RET fusion–positive lung and thyroid cancer. RET fusion testing strategies with rapid and reliable results are critical given recent FDA approval. Here, we assess various clinical assays in a large pan-cancer cohort. Experimental Design: Tumors underwent DNA-based next-generation sequencing (NGS) with...

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PMID: 33272981
DOI: 10.1158/1078-0432.ccr-20-3208

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