Article
Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations.
Blood - 5 Oct 2017
Durham Benjamin H, Getta Bartlomiej, Dietrich Sascha, Taylor Justin, Won Helen, Bogenberger James M, Scott Sasinya, Kim Eunhee, Chung Young Rock, Chung Stephen S, Hüllein Jennifer, Walther Tatjana, Wang Lu, Lu Sydney X, Oakes Christopher C, Tibes Raoul, Haferlach Torsten, Taylor Barry S, Tallman Martin S, Berger Michael F, Park Jae H, Zenz Thorsten, Abdel-Wahab Omar
Abstract excerpt
Classical hairy cell leukemia (cHCL) is characterized by a near 100% frequency of the BRAFV600E mutation, whereas ∼30% of variant HCLs (vHCLs) have MAP2K1 mutations. However, recurrent genetic alterations cooperating with BRAFV600E or MAP2K1 mutations in HCL, as well as those in MAP2K1 wild-type vHCL, are not well defined. We therefore performed deep targeted mutational and copy number analysis of cHCL (n = 53)...
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