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Article

Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype.

Kidney international - 1 Nov 2015

Kusunoki Yasuo, Matsui Isao, Hamano Takayuki, Shimomura Akihiro, Mori Daisuke, Yonemoto Sayoko, Takabatake Yoshitsugu, Tsubakihara Yoshiharu, St-Arnaud René, Isaka Yoshitaka, Rakugi Hiromi

Abstract excerpt

Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Despite its low affinity for the vitamin D receptor (VDR), both deficient and excessive 25(OH)D levels are associated with poor clinical outcomes. Here we studied direct effects of 25(OH)D3 on the kidney using 25(OH)D-1α-hydroxylase (CYP27B1) knockout mice. The effects of 25(OH)D3 on unilateral ureteral...

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PMID: 26176830
DOI: 10.1038/ki.2015.210

Genes

TNF
VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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