Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9

21 Sept 2006

Abstract excerpt

We previously showed that the calcium-binding protein S100A4 is overexpressed during the progression of prostate cancer (CaP) in humans and in the TRAMP (transgenic adenocarcinoma of the mouse prostate) mouse model. We tested a hypothesis that the S100A4 gene plays a role in the invasiveness of human CaP and may be associated with its metastatic spread. We observed that siRNA-mediated suppression of the S100A4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Protease and Inhibitor Mechanisms
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16990429
DOI: 10.1073/pnas.0606747103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9PMID 16990429Read ↗

The Role of S100A4 for Bone Metastasis in Prostate Cancer CellsSemantic proximity Read ↗

Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cellsSemantic proximity Read ↗

Activation of NF‐κB by extracellular S100A4: Analysis of signal transduction mechanisms and identification of target genesSemantic proximity Read ↗

Global gene expression profiling unveils S100A8/A9 as candidate markers in H-ras-mediated human breast epithelial cell invasion.Semantic proximity Read ↗

S100A4, a mediator of metastasis.Semantic proximity Read ↗

Effects of S100 calcium-binding protein A8 (S100A8) and S100 calcium-binding protein A9 (S100A9) on matrix metalloproteinase (MMP) expression in nasopharyngeal carcinoma CNE-2 cellsSemantic proximity Read ↗

CRISP3 expression drives prostate cancer invasion and progression.Semantic proximity Read ↗

RNA interference suppression of A100A4 reduces the growth and metastatic phenotype of human renal cancer cells via NF-kB-dependent MMP-2 and bcl-2 pathway.Semantic proximity Read ↗

Regulation of S100A2 expression by TGF-β-induced MEK/ERK signalling and its role in cell migration/invasionSemantic proximity Read ↗

Roles of calcium-binding proteins, S100A8 and S100A9, in invasive phenotype of human gastric cancer cells.Semantic proximity Read ↗

S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelial‑mesenchymal transition and activating the Wnt/β‑catenin pathwaySemantic proximity Read ↗

The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.