Article
MicroRNA-Dependent Control of Serotonin-Induced Pulmonary Arterial Contraction.
Journal of vascular research - 1 Jan 2017
Dahan Diana, Hien Tran Thi, Tannenberg Philip, Ekman Mari, Rippe Catarina, Boettger Thomas, Braun Thomas, Tran-Lundmark Karin, Tran Phan-Kiet, Swärd Karl, Albinsson Sebastian
Abstract excerpt
BACKGROUND: Serotonin (5-HT) is considered to play a role in pulmonary arterial hypertension by regulating vascular remodeling and smooth muscle contractility. Here, arteries from mice with inducible and smooth muscle-specific deletion of Dicer were used to address mechanisms by which microRNAs control 5-HT-induced contraction. METHODS: Mice were used 5 weeks after Dicer deletion, and pulmonary artery...
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