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Article

A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension.

American journal of respiratory and critical care medicine - 15 Jun 2015

Wallace Emma, Morrell Nicholas W, Yang Xudong D, Long Lu, Stevens Hannah, Nilsen Margaret, Loughlin Lynn, Mair Kirsty M, Baker Andrew H, MacLean Margaret R

Abstract excerpt

RATIONALE: Females are predisposed to pulmonary arterial hypertension (PAH); evidence suggests that serotonin, mutations in the bone morphogenetic protein receptor (BMPR) II gene, and estrogens influence development of PAH. The 5-hydroxytryptamine 1B receptor (5-HT1BR) mediates human pulmonary artery smooth muscle cell (hPASMC) proliferation. OBJECTIVES: We aimed to determine whether selected microRNAs (miRNAs)...

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Share to Bone Morphogenetic Protein Receptors, Type II
Share to Hypertension, Pulmonary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Muscle, Smooth, Vascular

Share to Pulmonary Artery

Share to Real-Time Polymerase Chain Reaction

Share to Receptor, Serotonin, 5-HT1B

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Source

Open in PubMed Open full text

Identifiers

PMID: 25871906
DOI: 10.1164/rccm.201412-2148OC
PMCID: PMC4476563

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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