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Article

Protection of melatonin in experimental models of newborn hypoxic-ischemic brain injury through MT1 receptor.

Journal of pineal research - 1 Jan 2018

Sinha Bharati, Wu Qiaofeng, Li Wei, Tu Yanyang, Sirianni Ana C, Chen Yanchun, Jiang Jiying, Zhang Xinmu, Chen Wu, Zhou Shuanhu, Reiter Russel J, Manning Simon M, Patel Nirav J, Aziz-Sultan Ali M, Inder Terrie E, Friedlander Robert M, Fu Jianfang, Wang Xin

Abstract excerpt

The function of melatonin as a protective agent against newborn hypoxic-ischemic (H-I) brain injury is not yet well studied, and the mechanisms by which melatonin causes neuroprotection in neurological diseases are still evolving. This study was designed to investigate whether expression of MT1 receptors is reduced in newborn H-I brain injury and whether the protective action of melatonin is by alterations of the...

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PMID: 28796402
DOI: 10.1111/jpi.12443

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