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Article

The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Oct 2011

Wang Xin, Sirianni Ana, Pei Zhijuan, Cormier Kerry, Smith Karen, Jiang Jiying, Zhou Shuanhu, Wang Hui, Zhao Rong, Yano Hiroko, Kim Jeong Eun, Li Wei, Kristal Bruce S, Ferrante Robert J, Friedlander Robert M

Abstract excerpt

Melatonin mediates neuroprotection in several experimental models of neurodegeneration. It is not yet known, however, whether melatonin provides neuroprotection in genetic models of Huntington's disease (HD). We report that melatonin delays disease onset and mortality in a transgenic mouse model of HD. Moreover, mutant huntingtin (htt)-mediated toxicity in cells, mice, and humans is associated with loss of the...

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Identifiers

PMID: 21994366
DOI: 10.1523/JNEUROSCI.3059-11.2011
PMCID: PMC3213696

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